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CAS 136-47-0 Tetracaine Hydrochloride Topical Anesthetic Ophthalmic Solution

Categories Local Anesthetic Powder
Place of Origin: China
Brand Name: YC
Certification: HSE, ISO 9001, USP, BP
MOQ: Negotiable
Price: Negotiable
Packaging Details: As you require
Delivery Time: 12 hours within your payment is received
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Supply Ability: 1000kg/month
Model Number: 136-47-0
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
storage temp.: Refrigerator
Usage: anesthetic (local) ; A local anesthetic used topically in opthalmology.
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    CAS 136-47-0 Tetracaine Hydrochloride Topical Anesthetic Ophthalmic Solution

    CAS 136-47-0 Tetracaine Hydrochloride Topical Anesthetic Ophthalmic Solution


    Usage anesthetic (local)
    Usage A local anesthetic used topically in opthalmology.
    Chemical Properties White Solid

    CAS 136-47-0
    MF C15H25ClN2O2
    MW 300.82
    EINECS 205-248-5
    mp 149°C
    storage temp. Refrigerator
    Product Categories
    API intermediates;
    Sodium channel;
    Amines;
    Aromatics;
    Intermediates & Fine Chemicals;
    Pharmaceuticals;
    Pharmaceutical intermediate;
    PONTOCAINE
    Synonyms:
    L AND OCAIN HYDROCHLORIDE;
    INTERCAIN HYDROCHLORIDE;
    MEETHOBALM HYDROCHLORIDE;
    2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;
    2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE;
    4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER HYDROCHLORIDE;
    4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE;
    4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL


    Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

    In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

    Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


    It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.


    A systematic review investigated tetracaine for use in emergency departments, especially for intravenous cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.


    Application
    Tetracaine drops are used for:
    Numbing the eye during certain procedures.

    Tetracaine drops are an anesthetic. It works by blocking nerve impulses, which results in loss of feeling.


    DESCRIPTION:
    Tetracaine Hydrochloride is a sterile aqueous topical anesthetic ophthalmic solution.

    Benzoic acid, 4-[butylamino]-, 2-[dimethylamino]ethyl ester, monohydrochloride.

    EACH mL CONTAINS: ACTIVE: Tetracaine Hydrochloride 5 mg (0.5%); INACTIVES: Boric Acid, Potassium Chloride, Edetate Disodium and Purified Water. Sodium Hydroxide and/or Hydrochloric Acid may be added to adjust pH (3.7 - 6.0). PRESERVATIVE ADDED: Chlorobutanol 0.4%.


    CLINICAL PHARMACOLOGY:
    Topical anesthetics stabilize the neuronal membrane and prevent the initiation and transmission of nerve impulses, thereby effecting local anesthesia. The onset of anesthesia usually begins within 30 seconds and lasts a relatively short period of time.


    INDICATIONS AND USAGE:
    For procedures in which a rapid and short-acting topical ophthalmic anesthetic is indicated such as in tonometry, gonioscopy, removal of corneal foreign bodies, conjunctival scraping for diagnostic purposes, suture removal from the cornea, other short corneal and conjunctival procedures.


    CONTRAINDICATIONS:
    Should not be used by the patient without physician supervision, or in those persons showing hypersensitivity to any component of this preparation. This product should never be prescribed for the patient’s own use.


    Product Specification
    Alternative Name:4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester . HCl
    Formula:C15H24N2O2 . HCl
    MW:264.3 . 36.5
    CAS:136-47-0
    Purity:≥98% (TLC)
    Appearance:White solid.
    Solubility:Soluble in water (>25mg/ml).
    Shipping:Ambient
    Long Term Storage:Ambient
    Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at - 20°C for up to 3 months.


    Local Anesthetic list
    NameCAS
    Articaine hydrochloride23964-57-0
    Benzocaine94-09-7
    Benzocaine hydrochloride23239-88-5
    Bupivacaine2180-92-9
    Bupivacaine hydrochloride14252-80-3
    Dibucaine hydrochloride61-12-1
    Levobupivacaine hydrochloride27262-48-2
    Lidocaine137-58-6
    Lidocaine hydrochloride73-78-9
    Pramoxine hydrochloride637-58-1
    Prilocaine721-50-6
    Procaine59-46-1
    Procaine hydrochloride94-09-7
    Proparacaine hydrochloride5875-06-9
    Propitocaine hydrochloride1786-81-8
    Ropivacaine hydrochloride132112-35-7
    Tetracaine94-24-6
    Tetracaine hydrochloride136-47-0
    Quality CAS 136-47-0 Tetracaine Hydrochloride Topical Anesthetic Ophthalmic Solution for sale
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