CAS 136-47-0 Tetracaine Hydrochloride Topical Anesthetic Ophthalmic
Usage anesthetic (local)
Usage A local anesthetic used topically in opthalmology.
Chemical Properties White Solid
storage temp. Refrigerator
Intermediates & Fine Chemicals;
L AND OCAIN HYDROCHLORIDE;
2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;
2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID
4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER
4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER
4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL
Tetracaine (also known as amethocaine) is a local anesthetic of the
ester anesthetic group. It is mainly used topically in
ophthalmology and as an antipruritic, and it has been used in
In biomedical research, tetracaine is used to alter the function of
calcium release channels (ryanodine receptors) that control the
release of calcium from intracellular stores. Tetracaine is an
allosteric blocker of channel function. At low concentrations,
tetracaine causes an initial inhibition of spontaneous calcium
release events, while at high concentrations, tetracaine blocks
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05%
adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose,
and throat surgery and in the emergency department where numbing of
the surface is needed rapidly, especially when children have been
injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential
Medicines, a list of the most important medications needed in a
basic health system.
A systematic review investigated tetracaine for use in emergency
departments, especially for intravenous cannulation in children, in
view of its analgesic and cost-saving properties. However, it did
not find an improvement in first-attempt cannulations.
Tetracaine drops are used for:
Numbing the eye during certain procedures.
Tetracaine drops are an anesthetic. It works by blocking nerve
impulses, which results in loss of feeling.
Tetracaine Hydrochloride is a sterile aqueous topical anesthetic
Benzoic acid, 4-[butylamino]-, 2-[dimethylamino]ethyl ester,
EACH mL CONTAINS: ACTIVE: Tetracaine Hydrochloride 5 mg (0.5%);
INACTIVES: Boric Acid, Potassium Chloride, Edetate Disodium and
Purified Water. Sodium Hydroxide and/or Hydrochloric Acid may be
added to adjust pH (3.7 - 6.0). PRESERVATIVE ADDED: Chlorobutanol
Topical anesthetics stabilize the neuronal membrane and prevent the
initiation and transmission of nerve impulses, thereby effecting
local anesthesia. The onset of anesthesia usually begins within 30
seconds and lasts a relatively short period of time.
INDICATIONS AND USAGE:
For procedures in which a rapid and short-acting topical ophthalmic
anesthetic is indicated such as in tonometry, gonioscopy, removal
of corneal foreign bodies, conjunctival scraping for diagnostic
purposes, suture removal from the cornea, other short corneal and
Should not be used by the patient without physician supervision, or
in those persons showing hypersensitivity to any component of this
preparation. This product should never be prescribed for the
patient’s own use.
|Alternative Name:||4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester . HCl|
|Formula:||C15H24N2O2 . HCl|
|MW:||264.3 . 36.5|
|Solubility:||Soluble in water (>25mg/ml).|
|Long Term Storage:||Ambient|
|Use/Stability:||Store, as supplied, at room temperature for up to 1 year. Store
solutions at - 20°C for up to 3 months.|
|Local Anesthetic list|